Building on expertise, research tools, technologies, capacities and collaborations established in NGFN-2 (e.g. within SMP-Cell), IG Cellular Systems Genomics generates knowledge on fundamental molecular, cellular, and disease-relevant processes. Our main objectives are

• to apply qualitative and quantitative functional genomic, proteomic, and cell biological strategies, in order to analyse the dynamics and cross-talk of signalling pathways and networks in vitro and in vivo.
• to generate systems genomics models that predict and validate novel markers for diagnosis and prognosis as well as target molecules with potential for therapeutic intervention.
• to validate the gained knowledge in breast cancer, where drug resistance mechanisms shall be elucidated. Here we aim to define routes that shall prevent acquired drug resistance and lead to tumour remission.

The Integrated Genome network IG-CSG is part of the National Program of Medical Genome Research (NGFN-Plus) and is funded by the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung - BMBF).